Week1
inflamatory response
Acute
healthy response to appropriate insult (infection, laceratoin, sprain, etc…) happens within seconds of injury
Main Causes:
- Physical Trauma
- Chemical Agents
- Thermal Extremes
- etc… (more listed on lecture slides)
Phases of Acute Inflamation:
- injury (lasts several minutes)
- soft tissue & vascular damage
- vasoconstriction
- damaged cells release chemical mediators including cytokines
- acute (acute phase of acute inflammation begins within a few minutes and lasts up to 3-4 days)
- vasodilation and blood vessel wall permeability increases
- WBC (neutrophils & macrophages) are released into the injured region
- it’s important to protect and localize inflamation
- Visual symptoms
- redness & heat (from increased circulation)/swelling (from more plasma)/pain (some from initial injury, increased sensitivity, some from swelling pressure), bruising (from initial injury tearing microvasculature, leading to blood pooling)
- destruction
- repair & modeling
- begins around 48 to 72 hours and typically lasts around 6 weeks
- maturation
In
Acute
Destruction
Repair
Matures
Chronic
Unhealthy and complicated response
Case example: obese diabetic fractures ankle could lead to chronic inflamation due to poor extremity circulation
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This content is still under construction